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Recent articles from the Lundbeck Foundation Centre for Fast-track Hip and Knee Replacement in Denmark

2012 May 8
by webmaster

During our recent lecture tour of Australia we were fortunate to meet lots of people doing some great work in orthopaedics. One person who really impressed us was Joanne Kenny from Austin Health in Melbourne. During the course of our conversations I spoke to her about the current evidence-base in orthopaedic enhanced recovery and I mentioned the impressive research work being completed in Denmark at the Lundbeck Centre. I recently shared a list of useful references with Joanne from the centre which I have detailed below. It’s a great reading list for anyone involved in orthopaedic enhanced reocvery.


1. Husted H, Andersen KV, Soballe K. Convalescence and sick leave following total knee and hip arthroplasty. Ugeskr Laeger 2009; 171:2892-2896.

2. Holm B, Kristensen MT, Myhrmann L, Husted H, Andersen LO, Kristensen B, Kehlet H.The role of pain for early rehabilitation in fast track total knee arthroplasty. Disabil Rehabil 2010; 32:300-306.

3. Andersen LO, Husted H, Kristensen BB, Otte KS, Gaarn-Larsen L, Kehlet H. Analgesic efficacy of subcutaneous local anesthetic wound infiltration in bilateral knee arthroplasty: a randomized, placebo-controlled, double-blind trial. Acta Anaesthesiol Scand 2010; 54:543- 548.

4. Andersen LO, Kristensen BB, Madsen J.L, Otte KS, Husted H, Kehlet H. Wound spread of radio labeled saline with multi- versus few-hole catheters. Reg Anesth Pain Med 2010; 35:200-202.

5. Kehlet H, Soballe K. Fast track hip and knee replacement – where are the issues? Acta Or- thopaedica 2010; 81:271-272.

6. Husted H, Otte KS, Kristensen BB, Ørsnes T, Wong C, Kehlet H. Low risk of thromboembolic complications in a fast track set up with hip and knee arthroplasty. Acta Orthopedica 2010; 81:599-605.

7. Husted H, Solgaard S, Hansen TB, Søballe K, Kehlet H. Care principles of four fast track arthroplasty departments in Denmark. Dan Med Bull 2010;57:A4166 1

8. Andersen LO, Husted H, Kristensen BB, Otte KS, Gaarn-Larsen L, Kehlet, H. Analgesic efficacy of local anaesthetic wound administration in knee arthroplasty. Volume vs. concentration. Anaesthesia 2010; 65:984-990.

9. Andersen LO. Husted H, Kristensen BB, Otte KS, Gaarn-Larsen, Kehlet H. Analgesic efficacy of intracapsular vs. intraarticular local anaesthetics after knee arthroplasty. Anaesthesia 2010;64:904-912

10. Andersen KV, Bak M, Christensen BV, Harazuk, Pedersen NA, Søballe K. A randomized controlled trial of local infiltration analgesia vs. epidural infusion for total knee arthroplasty. Acta Orthopedica 2010; 81:606-610.

11. Husted H Otte KS, Kristensen BB, Ørsnes T, Kehlet H. Readmissions after fast track hip and knee arthroplasty. Arch Orthop Trauma Surg 2010;130:1185-1191

12. Holm B, Kristensen MT, Bencke J, Husted H, Kehlet H, Bandholm T. Loss of knee-extension strength is related to knee swelling after total knee arthroplasty. Arch Phys Med Rehabil 2010; 91:1770-1776.

13. Krenk L, Rasmussen LS, Kehlet H. New insights into the pathophysiology of postoperative cognitive dysfunction. Acta Anaesthesiol Scand 2010;54:951-956

14. Larsen K, Hansen TB, Søballe K, Kehlet H. Patient reported outcome after fast-track hip arthroplasty and the need for additional rehabilitation. Health Quality Life Outcomes 2010; 8:144-154.

15. Jans Ø, Kehlet H, Hussain Z, Johansson P. Transfusion practice in hip arthroplasty – a nationwide study. Vox Sanguinis 2011: 100: 374-380

16. Lunn TH, Kristensen BB, Andersen LØ, Husted H, Otte KS, Gaarn-Larsen L, Kehlet H. Effect of high-dose preoperative methylpredisolone on pain and recovery after total knee arthroplasty: a randomised, placebo-controlled trial. Br J Anaesth 2011; 106:230-8. 2

17. Husted H, Troelsen A, Otte KS, Kristensen BB, Holm G, Kehlet H. Fast-track surgery for bilateral total knee replacement. J Bone Joint Surg 2011; 93-B: 351-6.

18. Holm B, Kristensen MT, Husted H, Kehlet H, Bandholm T. Thigh and knee circumference, knee extension strength, and functional performance after fast-track total hip arthroplasty. Phys Med & Rehabil 2011; 3: 117-24.

19. Jans Ø, Johansson P, Kehlet H. Blood transfusion in major orthopaedic surgery? Ugeskr Laeger 2011; 173: 815-817.

20. Krenk L, Rasmussen L.S. Postoperative delirium and Postoperative cognitive dysfunction in the elderly – what are the differences? Minerva Anestesiologica 2011;7:742-49

21. Lunn TH, Husted H, Solgaard S, Kristensen BB, Otte KS, Kjærsgaard AG, Gaarn-Larsen L, Kehlet H. Intraoperative local infiltration analgesia for Early Analgesia after total hip arthroplasty: A randomized double-blind placebo controlled trial. Reg Anesth Pain Med 2011; 5:424-29.

22. Otte K, Husted H, Ørsnes T, Kehlet H. Bilateral simultaneous total hip arthroplasty in a fasttrack setting. Hip International 2011; 3:336-339.

23. Andersen L, Otte KS, Husted H, Gaarn-Larsen L, Kristensen B, Kehlet H. High volume infiltration analgesia in total hip arthroplasty. A randomized, double blind placebo controlled trial. Acta Orthopedica 2011;82: 23-426

24. Kehlet H, Andersen LØ. Local infiltration analgesia in joint replacement: the evidence and recommendations for clinical practice. Acta Anaesthesiol Scand 2011; 7:778-784.

25. Husted H, Troelsen A, Kehlet H. Undocumented regimes in hip and knee replacement surgery may impair treatment outcome. Ugeskr Laeger 2011;25:1802-1805.

26. Husted H, Otte KS, Kristensen BB, Kehlet H. Fast-track revision knee arthroplasty – a feasibility study. Acta Orthopedica 2011;82 :438-40.

27. Husted H, Lunn TH, Troelsen A, Gaarn-Larsen L, Kristensen BB, Kehlet H. Why in hospital after fast-track hip and knee arthroplasty? Acta Orthopedica 2011; 82:679-684. 3

28. Husted H, Munk Jensen C, Solgaard S, Kehlet H. Reduced length of stay following hip and knee arthroplasty in Denmark 2000-2009. Acta Ortop Trauma Surg 2012; 132:101-104.

29. Munk S, Dalgaard J, Bjerggaard K, Andersen I, Hansen T. B, Kehlet H. Early recovery after fast-track Oxford unicompartmental knee arthroplasty, Acta Orthopedica 2012; 83:41-45.

30. Jakobsen TL, Husted H, Kehlet H, Bandholm T. Progressive strength training (10 RM) commenced immediately after fast-track total knee arthroplasty: Is it feasible? Disability Rehabil 2011; (e-pub)

31. Jans O, Bundgaard-Nielsen M, Solgaard S, Johansson PI, Kehlet H Orthostatic intolerance during early mobilization after fast-track total hip arthroplasty. Br J Anaesth 2012;108:436- 43

32. Holm B, Husted H, Kehlet H, Bandholm T. (2011) Effect of knee joint icing on knee- extension strength and knee pain elderly after total knee arthroplasty: A randomized cross- over study. Clinical Rehabilitation (e-pub)

33. Krenk L, Rasmussen LS, Bæk-Hansen T, Bogø S, Søballe K, Kehlet H. Delirium after fast- track hip and knee arthroplasty. Br J Anaesth 2012; 108:607-11.

34. Kjærsgaard-Andersen P, Kehlet H. Deep venous thrombosis prophylaxis in fast-track hip and knee replacement? Acta Orthop. 2012 (e-pub)

35. Lange J, Troelsen A, Thomsen RW, Søballe K. Chronic infections in hip arthroplasties: The risk of infection in one-stage and two-stage revisions – systematic review and meta- analysis. Clin Epidemiol 2012:57-73

36. Larsen K, Hansen TB, Søballe K, Kehlet H. Patient-reported outcome after fast-track knee arthroplasty. Knee Surg Sports Traum Arthrosc 2012 (e-pub)

37. Bandholm T, Kehlet H. Physiotherapy exercises after fast-track total hip and knee arthroplasty – time for reconsideration? Arch Phys Med Rehabil (e-pub) 4

38. Lunn T, Kristensen B, Gaarn-Larsen L, Husted H, Kehlet H. Post Anaesthesia Care Unit stay after total hip and knee arthroplasty under spinal anaesthesia – a prospective, observational study. Acta Anaesthesiol Scand 2012 (in press)

39. Munk S, Jensen NJF. Andersen I, Kehlet, H, Hansen TB. Effect of compression therapy on knee swelling and pain after total knee arthroplast. Knee Surg Sports Traum Arthroscopy 2012 (in press)

40. Jans Ø, Johansson P, Kehlet H. Mortality after primary total hip arthroplasty and possible relations to transfusion. Vox Sanguinis 2012 (in press)


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